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QY球友会生物荣获：“10X Genomics 中国单细胞及空间组学优选服务商”
科研技术服务平台多样 满足不同样本实验需求
▲QY球友会生物（部分）技术平台展示
| 序号 | 提供服务 | 技术平台 | 应用方向 | 服务样本保障 |
| 一 | 单细胞核 RNA 测序 【科研服务】 |
10X Genomics | ★冰冻组织。 ★FFPE 样本。
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伯优® QY球友会生物独研 细胞核分离试剂盒 |
| 二 | 单细胞 RNA 测序 【科研服务】 |
1、高通量平台： 10X Genomics；BD Rhapsody； 2、低通量平台： SMART-seq 2。 |
★肿瘤异质； ★肿瘤免疫微环境； ★胚胎发育； ★细胞分化。 （受细胞活率，悬液单胞率等影响）。 |
伯优® QY球友会生物独研 单细胞样本保存液 无惧异地时效影响 |
| 三 | 单细胞 ATAC 测序 【科研服务】 |
10X Genomics | ★肿瘤异质性； ★免疫微环境； ★神经科学； ★胚胎发育； ★细胞分化等领域的研究。 |
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| 四 | 单细胞 TCR/BCR 测序 （单细胞免疫组库测序） 【科研服务】 |
10X Genomics BD Rhapsody |
10X genomics 提供了全面的单细胞免疫分析方案； 通过精简的工作流程，可以实现从样品到文库准备、 免疫测序和软件分析全套解决方案， 揭示 T 和 B 细胞多样性、 V(D)J 重组和免疫细胞分析。 |
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| 五 | 单细胞 ATAC+RNA 测序 （单细胞多组学联合） 【科研服务】 |
10X Genomics | ★干细胞； ★免疫； ★癌症； ★神经科学。 |
伯优® QY球友会生物独研 单细胞样本保存液 无惧异地时效影响 |
| 六 | 单细胞全长转录本测序 【科研服务】 |
Nanopore | ★发现不同细胞携带的突变，携带突变的细胞与非突变 细胞相比，挖掘基因表达规律。 ★挖掘基因功能（如膜蛋白、分泌蛋白、转录因子等 编码基因转录本使用情况，并发现全新功能的转录本）。 ★发现融合基因所在的细胞亚群，研究它们与肿瘤细胞 的拟时序分化关系。 ★发现亚群特异性的全新 lncRNA。 ★获得亚群特异性表达的转录本，能够辅助小核酸类药 物开发企业等。 |
伯优® QY球友会生物独研 单细胞样本保存液 无惧异地时效影响 |
| 七 | 空间转录组测序 【科研服务】 |
10X Genomics Visium | ★空间位置信息，或者细胞在组织中天然的状态。 ★肿瘤学； ★免疫学； ★发育生物学； ★神经科学； ★病理学等方向。 |
伯优® QY球友会生物独研 单细胞样本保存液 无惧异地时效影响 |
| 八 | FFPE 空间转录组测序 【科研服务】 |
10X Genomics Visium | ★空间位置信息，或者细胞在组织中天然的状态。 ★肿瘤学； ★免疫学； ★发育生物学； ★神经科学； ★病理学等方向。 |
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| QY球友会生物 10X Genomics 仪器平台 |
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| 仪器平台名称 | Chromium Controller | Chromium X |
| 原理 | Next GEM | Next GEM |
| 单次运行样本数 | 8 | 16 |
| 捕获细胞数 | 500-10，000 | 2，000-20,000 |
| 捕获效率 | 65% | 65% |
| 双细胞率 | 0.8% per 1000 cells | 0.4% per 1000 cells |
| 兼容性 | 不兼容新试剂 | 兼容旧试剂 |
| 序号 | 协助客户发表文章 | 杂志 | IF | 日期 | 样本类型 |
| 1 | Characterization of Cancer Stem Cells 1 in Laryngea Squamous Cell Carcinoma by Single-cell RNA Sequencing | Genomics, Proteomics & Bioinformatics | 11.5 | 2024 Sep 6 | 人喉癌组织 |
| 2 | Disrupting YAP1-mediated glutamine metabolism induces synthetic lethality alongside ODC1 inhibition in osteosarcoma | CELLULAR ONCOLOGY | 4.9 | 2024 Aug 08 | 人细胞 |
| 3 | RAC1 inhibition ameliorates IBSP-induced bone metastasis in lung adenocarcinoma | Cell Reports | 7.5 | 2024 Jul 24 | 人肺癌骨转移 |
| 4 | Single-cell RNA-seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitis |
Journal of the European Academy of Dermatology and Venereology | 9.2 | 2023 Nov | 人皮肤 |
| 5 | Abnormal metabolism in melanocytes participates in the activation of dendritic cell in halo nevus | CLINICAL IMMUNOLOGY | 8.6 | 2024 Jun 29 | 人晕痣 |
| 6 | Activation of CD14+ Monocytes via the IFN-γ Signaling Pathway Is Associated with Immune-Related Adverse Events in Hepatocellular Carcinoma Patients Receiving PD-1 Inhibition Combination Therapy |
biomedicines | 3.9 | 2024 May 21 | 人外周血 |
| 7 | Distinct roles of TREM2 in central nervous system cancers and peripheral cancers | Cancer Cell | 50.3 | 2024 May 23 | 小鼠脑胶质瘤 |
| 8 | Calcified apoptotic vesicles from PROCR+ fibroblasts initiate heterotopic ossification |
J Extracell Vesicles | 16 | 2024 Apr | 大鼠肌腱 |
| 9 | Landscape of gut mucosal immune cells showed gap of follicular or memory B cells into plasma cells in immunological non-responders | Clinical and Translational Medicine | 10.6 | 2024 May 23 | 人 Ileocyte 粘膜组织样本 |
| 10 | Dissecting microenvironment in cystadenomas and hepatic cysts based on single nucleus RNA-sequencing data | COMPUTERS IN BIOLOGY AND MEDICINE | 7.7 | 2024 May 03 | 人肝囊肿 |
| 11 | Mapping cell diversity in human sporadic cerebral cavernous malformations | GENE | 3.5 | 2024 May 22 | 人石蜡样本 |
| 12 | An advanced comprehensive muti-cell-type-specific model for predicting anti-PD-1 therapeutic effect in melanoma | Theranostics | 12.4 | 2024 Mar 03 | 人骨软组织 |
| 13 | Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes | Nature Communications | 16.6 | 2024 Feb 06 | 小鼠脾细胞 |
| 14 | Deciphering the heterogeneity of neutrophil cells within circulation and the lung cancer microenvironment pre- and post-operation | CELL BIOLOGY AND TOXICOLOGY | 6.1 | 2024 Feb 06 | 人组织 / 血液 |
| 15 | Mrc1+ macrophage-derived IGF1 mitigates crystal nephropathy by promoting renal tubule cell proliferation via the AKT/Rb signaling pathway |
Theranostics | 12.4 | 2024 Feb 17 | 小鼠肾组织 |
| 16 | Radiotherapy-Induced Astrocyte Senescence Promotes anImmunosuppressive Microenvironment in Glioblastoma to Facilitate Tumor Regrowth | Advanced Science | 15.1 | 2024 Feb 11 | 小鼠大脑组织 |
| 17 | Single-cell transcriptomic analyses of tumor microenvironment and molecular reprograming landscape of metastatic laryngeal squamous cell carcinoma |
Communications Biology | 5.9 | 2024 Jan 08 | 喉癌组织 |
| 18 | Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single-Cell Transcriptomics |
Advanced Science | 15.1 | 2023 Nov 22 | 人肺癌组织 |
| 19 | Single-cell and spatial heterogeneity landscapes of mature epicardial cells | Journal of Pharmaceutical Analysis | 8.8 | 2023 Jul 22 | 小鼠心脏 |
| 20 | FOXG1 drives transcriptomic networks to specify principal neuron subtypes during the development of the medial pallium |
DEVELOPMENTAL NEUROSCIENCE | 13.116 | 2023 Mar 10 | 小鼠脑 |
| 21 | Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an antiferroptotic target in osteoarthritis |
EBioMedicine | 5.736 | 2022 Sep 19 | 人软骨 |
| 22 | Microtubule stabilization targeting regenerative chondrocyte cluster for cartilage regeneration |
Theranostics | 8.579 | 2023 Jun 12 | 人软骨 |
| 23 | Single-Cell Sequencing Informs That Mesenchymal Stem Cell Alleviates Renal Injury Through Regulating Kidney Regional Immunity in Lupus Nephritis |
STEM CELLS AND DEVELOPMENT | 4 | 2023 Aug 8 | 小鼠肾脏 |
| 24 | The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity | Cell Metabolism | 29 | 2023 Aug 04 | 结直肠癌组织 |
| 25 | Role and Therapeutic Potential for Targeting Fibroblast Growth Factor 10/FGFR1 in Relapsed Rheumatoid Arthritis | Arthritis and Rheumatology | 13.3 | 2023 Aug 16 | 人滑膜组织 |
| 26 | A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia | Nature Communications | 16.6 | 2023 Aug 04 | 人食管下括约肌 & 血液 |
| 27 | Single-cell RNA sequencingreveals the Muller subtypes andinner blood-retinal barrierregulatory network in earlydiabetic retinopathy | Frontiers in Molecular Neuroscience | 6.261 | 2022 Dec 01 | 人视网膜 |
| 28 | Single-Nucleus Transcriptome Profiling of Locally Advanced Cervical Squamous Cell Cancer Identifies Neural-Like Progenitor Program Associated with the Efficacy of Radiotherapy |
Advanced Science | 15.1 | 2023 Jul 09 | 人宫颈肿瘤 |
| 29 | Updated skin transcriptomic atlas depicted by reciprocal contribution of single-nucleus RNA sequencing and single-cell RNA sequencing | JOURNAL OF DERMATOLOGICAL SCIENCE | 4.6 | 2023 Jun 20 | 人皮肤 |
| 30 | SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches | CELL RESEARCH | 46.297 | 2023 May 04 | 小鼠腿骨 |
| 31 | The role of signaling crosstalk of microglia in hippocampus on progression of ageing and Alzheimer’s disease | Journal of Pharmaceutical Analysis | 14.026 | 2023 May 15 | 小鼠海马 |
| 32 | General anesthetic action profile on the human prefrontal cortex cells through comprehensive single-cell RNA-seq analysis | iScience | 6.107 | 2023 Apr 21 | 人大脑前额叶皮质组织 |
| 33 | Single-cell RNA sequencing highlights intratumor heterogeneity and intercellular network featured in adamantinomatous craniopharyngioma |
SCIENCE ADVANCES | 14.957 | 2023 April 12 | 人颅咽管瘤 |
| 34 | Tumor microenvironment remodeling after neoadjuvant immunotherapy in non‑small cell lung cancer revealed by single‑cell RNA sequencing |
Genome Medicine | 15.266 | 2023 Mar 03 | 人血液 / 肺癌组织 |
| 35 | Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy | Journal of Hepatology | 30.083 | 2023 Jan 25 | 人肝脏 |
| 36 | Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice |
Diabetologia | 10.46 | 2023 Jan | 小鼠胰腺 |
| 37 | Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity | Cell Reports | 9.995 | 2023 Jan 18 | 小鼠细胞 |
| 38 | Single-cell RNA-sequencing uncovers compound kushen injection synergistically improves the efficacy of chemotherapy by modulating the tumor environment of breast cancer |
Frontiers in Immunology | 8.786 | 2022 Oct 30 | 小鼠乳腺（癌）组织 |
| 39 | A YAP/TAZ-CD54 axis is required for CXCR2 −CD44 − tumor-specific neutrophils to suppress gastric cancer | Protein & Cell | 15.328 | 2022 Oct 26 | 人小鼠血液 |
| 40 | Single-cell dissection of remodeled inflammatory ecosystem in primary and metastatic gallbladder carcinoma |
Cell Discovery | 38.079 | 2022 Oct 05 | 人胆囊组织 |
| 41 | Defining Specific Cell States of MPTP-Induced Parkinson’s Disease by Single-Nucleus RNA Sequencing | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 6.208 | 2022 Sep 15 | 小鼠脑 |
| 42 | Single‐cell transcriptome atlas reveals protective characteristics of COVID‐19 mRNA vaccine |
Journal of Medical Virology | 20.693 | 2022 Sep 19 | 人肺组织 |
| 43 | Tumor-polarized GPX3+ AT2 lung epithelial cells promote premetastatic niche formation |
PNAS | 12.779 | 2022 Jul | 小鼠肺组织 |
| 44 | Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Acute Myocardial Infarction | frontiers in immunology | 8.786 | 2022 Jun 29 | 人外周血 |
| 45 | Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s Disease-like neurodegeneration by causing energy metabolism disorders in mice | Journal Of Hazardous Materials | 14.224 | 2022 Feb 11 | 小鼠脑组织 |
| 46 | Patient-derived organoids for personalized gallbladder cancer modelling and drug screening |
Clinical and Translational Medicine | 8.554 | 2022 Jan | 人胆囊组织 |
| 47 | Anatlas of dynamic peripheral blood mononuclear cell landscapes in human perioperativeanaesthesia/surgery | Clinical and Translational Medicine | 8.554 | 2022 Jan | 人外周血 |
| 48 | Single-nucleus transcriptomic atlas of spinal cord neuron in human | Elife | 6.4 | 2021 Sep 30 | 人脑组织 |
| 49 | Single-cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Ang II-Induced Abdominal Aortic Aneurysms |
DNA AND CELL BIOLOGY | 3.55 | 2021 Nov | 小鼠肾上腹主动脉 |
| 50 | iNKT subsets differ in their developmental and functional requirements on Foxo1 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 12.779 | 2021 Nov 16 | 小鼠骨髓 |
| 51 | Inherent hepatocytic heterogeneity determines expression and retention of edited F9 alleles post-AAV/CRISPR infusion | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 12.779 | 2022 Oct | 小鼠肝组织 |
| 52 | Single-cell profiling of tumor-infiltrating TCF1/TCF7 + T cells reveals a T lymphocyte subset associated with tertiary lymphoid structures/organs and a superior prognosis in oral cancer | ORAL ONCOLOGY | 5.972 | 2021 May 25 | 人口腔组织 |
| 53 | A novel recombinant cccDNA-based mouse model with long term maintenance of rcccDNA and antigenemia | Antiviral Res | 10.103 | 2020 Aug | 小鼠肝组织 |
| 54 | In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9- activator transgenic mice |
Nature Neuroscience | 28.771 | 2018 Mar | 小鼠脑组织 |
| 55 | Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and transcriptional activities of ECs in CC | Molecular Therapy-Nucleic Acids | 10.183 | 2021 Apr 2 | 人宫颈癌组织 |
| 56 | A TNFR2-hnRNPK axis promotes primary liver cancer development via activation of YAP signaling in hepatic progenitor cells | Cancer Res | 13.312 | 2021 Feb 22 | 人肝组织 |
| 57 | Characterization of the heterogeneity of endothelial cells in bleomycin‑induced lung fibrosis using single‑cell RNA sequencing |
Angiogenesis | 10.658 | 2021 May | 小鼠肺组织 |
| 58 | Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain | Cell Research | 46.297 | 2021 Mar 10 | 小鼠腓肠神经 |
| 59 | Liver type 1 innate lymphoid cells develop locally via an interferon-g–dependent loop | Science | 63.714 | 2021 Mar 26 | 小鼠肝脏细胞 |
| 60 | Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodules | 38.079 | 2020 | 人肺癌组织 | |
| 61 | Somatosensory neuron types identified by high-coverage single-cell RNA sequencing and functional heterogeneity | 46.297 | 2015 | 小鼠背根神经节 |
为什么要选择QY球友会生物？
1、QY球友会生物按客户需求真实开展实验，不辜负每一位客户的倾心托付。
2、QY球友会生物已通过 ISO9001:2015 国际质量标准认证，实验项目服务有保障。
3、QY球友会生物实验团队项目经验丰富，从样本到数据，实验质量有保障。
4、至今，风雨兼程 15 载，QY球友会生物与科研工作者共同携手，累计发布 SCI 论文 2500 余篇。平均影响因子大于 7.2 分。
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